What to Watch: The Marvelous Mrs. Maisel (which just won the Golden Globe) is an Amazon series about a Jewish housewife turned stand-up comedian. It takes a little while to warm up, but I’ve been digging it so far. Give it a try.

+ What to Welcome Back: David Letterman is back on television with a very different vibe (and that beard). My Next Guest Needs No Introduction kicks off Letterman’s interview series with Barack Obama. It’s not particularly funny. And it’s nothing you haven’t heard before. But it’s a lot of things you haven’t heard for a while.

+ What to Consider: “Once Jennifer was diagnosed with myalgic encephalomyelitis (ME), commonly known as chronic fatigue syndrome (CFS), she and her new husband, Omar, were left to grapple with how to shape a future together in the face of a lifelong illness.” It’s brutal to deal with a debilitating illness or pain syndrome. Matters are made worse if that syndrome can’t be effectively diagnosed or treated. Filmmaker Jennifer Brea shares her stories (and finds many others who are suffering from similar symptoms): Unrest on PBS.